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Fletta eftir efnisorði "Chemical and Drug Induced Liver Injury"

Fletta eftir efnisorði "Chemical and Drug Induced Liver Injury"

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    Clinical management of patients with drug-induced liver injury (DILI) 
    Björnsson, Einar Stefán (2021-06-28)
    Drug-induced liver injury (DILI) should be considered in all patients with recent elevation of liver tests without obvious etiology and normal hepatobiliary imaging. There is currently no biomarker that is helpful in diagnosis which relies on clinical ...
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    A revised electronic version of RUCAM for the diagnosis of DILI 
    Hayashi, Paul H; Lucena, M Isabel; Fontana, Robert J; Björnsson, Einar Stefán; Aithal, Guruprasad P; Barnhart, Huiman; Gonzalez-Jimenez, Andres; Yang, Qinghong; Gu, Jiezhun; Andrade, Raul J; Hoofnagle, Jay H (2022-07)
    BACKGROUND AND AIMS: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network (DILIN) and the Spanish DILI ...
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    Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans 
    Ravindra, Kodihalli C; Vaidya, Vishal S; Wang, Zhenyu; Federspiel, Joel D; Virgen-Slane, Richard; Everley, Robert A; Grove, Jane I; Stephens, Camilla; Ocana, Mireia F; Robles-Díaz, Mercedes; Isabel Lucena, M; Andrade, Raul J; Atallah, Edmond; Gerbes, Alexander L; Weber, Sabine; Cortez-Pinto, Helena; Fowell, Andrew J; Hussaini, Hyder; Björnsson, Einar Stefán; Patel, Janisha; Stirnimann, Guido; Verma, Sumita; Elsharkawy, Ahmed M; Griffiths, William J H; Hyde, Craig; Dear, James W; Aithal, Guruprasad P; Ramaiah, Shashi K (2023-03-03)
    Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of ...